Whether you need more than one run depends on the quality of wire. I buy welding wire rated at 350A for up to 50 foot runs, more than that is just wasting money. And the wire is extrememly cheap compared to all the car audio ripoff brands. Save yourself money and get wire here: https://weldingsupply.com/cgi-bin/br....pl?SIGNOUT::1

An average of $3 a foot compared to the $5-6 a foot people pay for "branded" wire. It kills me to see people waste money on inferior wire.