building a bottom end.. the rule is get the compression up as high as you can, and get the rods upgraded the best you can... its the only thing that will make it worth the $1500+ (weither you pay it or not) amount of machine work required to build it.

If you put the right parts in, you can get the money back later.

As far as your setup goes otherwise... E85 + s1x cam = 3.0 pulley and 360+whp on a 10:1 bottom end... aka it will work fine.