I am of the opinion that if you can keep everything sealed up and topped off, you are probably okay for the most part.
But as I have stated earlier, Dex Cools sensitivity to air makes me to not run it because the cooling system is not one of those things you give a lot of thought to in the grand scheme of automotive maintenance. Furthermore, how long after developing a leak in something like the LIM, will it be before you notice? And all that time Dex is being exposed to air and potentially turning to garbage in your engine.
If not for the oil analysis it may have been a really long time before I knew about it as I was not loosing coolant in any significant amount that. The safe thing to do in my opinion and based on my experience is to just flush it.
I will add also, that Dex Cools chemistry does not show up on oil analysis the same either. I could tell based on my reports and just from experience in reading them that there was a coolant leak, but it wasnt until I switched to the green coolant that it clearly showed up in the normal way on the oil analysis report.
The point is that there are things that make Dex Cool suspect and things about its chemistry that may further aggravate diagnosing an issue.