A few things.
I have a 97 grand prix that I converted to E85... I was able go from stock horsepower to around 300whp without doing ANY mods but putting a smaller pulley on and changing the injectors.
If you put 42# injectors in, you will not have to tune for E85 at all, which is handy, and the stock tune works GREAT with E85. You can also push the limits of those 42# injectors to about 310whp on a stock tune and stock fuel pressure... You could try to up the fuel pressure a bit when you do your fuel system if you wanted to stretch them... its usually easier than tuning for guys that dont have easy access to tuning options.
You could then upgrade from there, and 60# injectors would be needed, as well as tuning being a good idea at that point.