I have the MSD packs and have had them going on 2 years with zero issues. I wont get the mud all stirred up, all I will say is I have no regrets.
As for the plugs, As a general rule, an engine may benefit from a colder grade of plug where modifications made have increased the temperature in the combustion chamber (increased turbo boost, nitrous oxide use, increased compression), colder plug will conduct heat away from the firing tip more quickly and thus help reduce detonation/plug damage.