Sticky??? Nah.
In short, E85 is great and does awesome things for power and keeping things safe in the preformance department. After that everything is a con. Lower mpgs, more trips to the pump, more money spent, not every station has it and if you travel you need to worry about how far till the next place with E85. Thats just the skinny.
Just to note, a new fuel filter is a must. You don't want to run a old filter thats had regular gasoline running through it for thousands of miles.