It's probably safe to assume this isn't the issue since the plugs and wires have been changed twice, but I'll just put this out there anyway... Last time I did my plugs and wires, I had a misfire on cylinder #3 and it was just because the wire wouldn't seat correctly on the plug. I didn't realize there was anything wrong until I was on my way to work, and the wire wiggled loose and the SES started flashing. I exchanged the wires and all was well.