They can work, they'll be louder than hell with a hundred watts on them though.
A pair of those on 100 watts each = over 120 dB....
They HAVE to be in a ported box else you won't have and bass and you might damage them. If you do put them in a ported box, make sure you run them with a crossover.
Example, tune the box to 60 Hz then cross them over at 80 Hz. That'll be loud as hell, and still sound decent.
If I were to do a budget home speaker build, I'd be using pro drivers for sure.
Yeah you can drill the box right onto the sheet metal back there, just line it with silicone so it creates an air tight seal.
I'd look for an amp that can do around 50-100 watts on two channels.
That'd be more than enough for that type of speaker.