People replace the lifters or delete the system entirely because the DoD lifters collapse and fail. They will cause a permanent misfire and even in some extreme cases break and damage the camshaft. The early DoD stuff from 2005-2009ish was prone to oil consumption too when it went down into 4 cylinder mode. The LS4 is known to eat oil.

If you just want it disabled it will require a tune or the AFM disabler thing that they sell on amazon/ebay that plugs into the OBD2 post.