youre going to need bigger injectors and a tune. you then need to change your fuel filter a few times after you start running it because it will clean out all the junk in your tank. depending upon how much fuel you are using (your mod lists extensiveness) you may need a bigger fuel pump and a fuel pump rewire. with a basic setup, 42.5# injectors should be fine, but if youre running in the sub-3.2 ish pullies you will definately need 65# injectors.

the lines and everything will not be affected. ethanol is not corrosive.