1. Some tuning with HP tuners. I have a 97 PCM so it may be different than an 07. Easy way is to lie to PCM as to injector size (tell them they are 30%+- smaller than they really) which leads to the 30% more fuel E-85 requires. Timing needs to be increased then quite a bit under high load/WOT areas for the E-85.
2. Research as many threads as you can find on the subject.