I wouldn't recommend getting them for the 3rd brake light. I've also heard that the cruise control won't work (GM's way of telling you the bulb is out, similar to hyperflash for the turn signals).
Also, and more importantly, LED's are directional. They won't fill the housing like a filament bulb, and in our CHMSL will be much harder to see.
Other hints:
Get red LED's for behind red lenses (tail lights, etc). They'll be brighter than white LED's, and the white LED's will look slightly pink behind the red lens.
Where do you plan on mounting the 12" strip for the 3rd reverse light?