There probably isnt that much difference in a couple * of timing at cruise. I played around and couldnt tell much of a difference once I got above 40. Because pump e85 is so inconsistent (and ****ty for that matter), I wouldn't think you see much difference at cruise. The difference is in the WOT and boost level. But my "opinion" is usually not welcomed on that particular matter when it comes to E85. but I digress...

Just make sure however high you go at cruise that its a smooth flow increasing and decreasing....