If you have any motion sickness at all you should take some pills or whatever for it before you leave. I don't get bad motion sickness but i get it a little and for my honeymoon we went from dayton to chicago then to puerto rico and i felt sick for the first 2 days we were there. Wish i would have taken something for that before i left but i didn't. That was my first flight and I wouldn't have any problem with doing it again just make sure i have something in my system first.