The gun you get should depend a little bit on how you intend to use it.
I own two pistols. The first is a Glock G17 (kind of wish I would have bought a G19 instead because the G17 is almost impossible to carry concealed) for personal defense, and the second is a S&W 22-A1 Custom that I use for target practice and soon for competition.
I'm assuming you want something to keep around just in case and maybe carry with a CCW license. I love my Glock and will recommend it to anyone looking to purchase a handgun, but I will warn you to consider the size of the gun you buy. Make sure it's not too big to carry, or to small to comfortably handle.
And for God's sake, go out and practice with the darn thing!
