Going with what six said above, one of the main things needed to be looked at is what the tune was designed for and what you're actually running for mods. There actually was a list created about 5-7 years ago that listed motor failures, mods and pcm being used, have to dig up the link.

If you actually open up each of the tunes in an editor you will see some major differences in the zzp's from intense/dhp.