Not quite sure if you should or not, but I used thread sealant b/c there semed to be a small amount on the LIM and Supercharger bolts when I pulled them out. I figure it probably can't hurt anything by making sure it's sealed up tight. I've got about 10,000 miles on the newer gasket, so I'm sure it helped. I put just a little dab and rubbed it around the threads.