Post the exact codes it spit out on the scanner. There are a lot of different misfire codes.
Try soaking the O2 sensor with PB Blaster or some other good penetrating oil where it meets the manifold. A torch also comes in handy on this as you can heat the manifold bung around the O2 and while it's warm try backing it out. May have to loosen/tighten a few times to get it to move. I've used a pipe wrench to back out a stubborn sensor that rounded off.
You have to get that sensor installed or it's never going to run right.