For mine, I have a 4ch 800 watt sony pushing my highs. The doors on the first 2 channels and the rears on the other 2. My amp also has the high, mid, and low filter on it. So if yours has that, I would run the doors and the 4's on 2 channels together on the high filter and the 6X9's on the other to on the mid filter and adjust your gains accordingly. If your amp doesn't have this, you can buy a crossover and do the same thing. Depends on how much money you want to put into it. But this is a basic set up to get you started. Can always add more later on.