Yes but they will sound like S#*T, the monsoon amp puts out separate low frequencies to the two 6x9 subwoofers, that would be the lt green/black and dk blue/white wires, and the other frequencies to the smaller 3.5' speakers within the subwoofers,this would be the lt blue- and dk blue + for the right speaker and yellow - and brown + for the left speaker, you could just try the latter wire to your new 6x9 but you will have no lows, or you could hook up these wires to your tweeters on the new speakers and the dk blue/white and lt green/black wires to the woofers( this has been done here before) but I wouldn't recommend it. I would just rather replace with new monsoon speakers if yours are shot or install entirely new and different amp if you are up to it , I did the latter and also replaced the front speakers with Polk 6.5" components also