Absolutely. Ethanol contains 76,100 BTU/gal where gasoline contains 114,000 BTU/gal. 10% Ethanol results in close to 111836 BTU/ga. The difference is not huge but it is there.
You will read about people making lots of power from E85 in a forced induction engine. That fuel while it has much less BTU's a gallon has a higher octane rating. You can simply burn a lot more of it to make up the difference. This allows for running more timing on more boost without knock retard.