I run e85 daily, I go to college 350 miles from where I live and often drive back to see my girlfriend. I get around 18-24 MPG (Cammed, Turbo, e85) @ 80mph on the interstate. The car drives like its gas but hella faster and "cleaner" (Who gives a f****)... Cold start just requires tuning and its fine. I ran my e85 car in -20* weather.... its fine. Just get a damn good tune.