I'd run headers then a 75 shot would be ok. Thats about the max I would run on a stock internal built engine as well. You would be pushing a 75 shot on manifolds.
You will have to run atleast one stage colder plugs, and start your plug gap at .035" and work your way up. Most cant go larger than .042" before they get misfires under boost and juice. I personally run mine at .035" and call it a day when spraying. I played around with the plug gap, and found out that size works best for me, but everyone's engine is different.
Build the engine to take it from the bottom up and you can run a much healthier shot, but there are still limitations to your madness.
~F~