For the blower, hes probably talking about the knocking noise, 99% of the time, thats just a worn, bad OEM coupler that can be upgraded to a bomb proof green after market one for around $30.00 + new supercharger oil.
Transmissions, sure, just like any other car...if its flogged and abused, then sure it can go out. Probably no scheduled maintenance, such as fluid or filter changes, or always doing burn outs and only one wheel spinning shelling the differential. Or, could just be a bad wire to it or inside of it, or even a sensor causing it not to run right.
~F~