Newer cars do this much easier, since they actually have a way to measure the ethanol content and adjust the ECU accordingly. We have to do this manually to the w-body platforms, as they were not equipped with the software or sensors at that time. Hence why one would have to manually check the ethanol content in a given tank of fuel, and then adjust the stoichiometric targets in the tune to really dial it in.
Note that E85 is pretty forgiving though. As in even this coming winter, when it is more like E70, than E85, I will not change my tune. I will just let it run on the rich side for several months (unless I have some issues, which I would report to this thread if so!)