Ok so this should be an easy thing to diagnose right?

Well, I have swapped coils and Cyl 1 and 4 still show misfires in the the Torq App, another interesting fact is that around town driving, stop and go, there are no misifres being detected, but if I am driving on the Interstate it starts misfiring.

Currently I have a 3.6 pulley, AL104's, 3" downpipe no cat, intake, ported blower. Again this only does this at high speeds, my initial thoughts is that since the rear O2 is tuned out and I plugged the O2 bung with an O2 bung cover (the bolt that comes in headers that have O2 bungs), that maybe it is the tune. I tried different coil packs and it still does it only on 1 and 4.